Optic Nerve Neuropathy

Glaucoma is an optic nerve neuropathy, in which vision is lost – not due to elevated IOP – but due to the death of the retinal ganglion cells which carry the visual signal from the retina to the brain. Trabodenoson’s clinical profile already includes IOP lowering with a good safety profile. The molecule’s neuroprotective profile, documented in an animal model of acute ocular hypertension, has the potential to significantly change how glaucoma is managed, including supporting earlier preventive medical treatment in a much larger population of patients.

In a preclinical model of retinal ischemia secondary to acute ocular hypertension, topical trabodenoson treatment (with eye drops) was able to protect approximately 100% of retinal ganglion cells (RGCs) from death secondary to the ischemic insult.